Respiratory manifestations of post-COVID syndrome

Overcoming infection with coronavirus disease 2019 (COVID-19) can lead to the persistence of various symptoms in some patients. The complex of symptoms causally related to severe acute respiratory coronavirus 2 infection is called post-COVID syndrome. One of the most common respiratory complications is pulmonary fibrosis, especially after critical course of the disease. In some patients, ho-wever, only the peripheral airways are affected by the air-trapping seen on high-resolution computed tomography scans. Less common respiratory complications include sarcoidosis and pneumatoceles. This narrative review summarizes current knowledge about pulmonary involvement as part of post-COVID syndrome.

Experiences of improvement of everyday life following a rehabilitation programme for people with long-term cognitive effects of COVID-19: Qualitative study.

AIM AND OBJECTIVES: To explore challenges in everyday life for people with long-term cognitive effects of COVID-19 and whether a rehabilitation programme contributed to the remedy thereof. BACKGROUND: Healthcare systems around the world need knowledge about acute COVID-19 treatment, long-term effects exerting an impact on peoples' everyday lives, and how to remedy these. DESIGN: This is a qualitative study with a phenomenological approach. METHODS: Twelve people with long-term cognitive effects of COVID-19 participated in a multidisciplinary rehabilitation programme. Individual semi-structured interviews were made. Data were analysed thematically. RESULTS: Three themes and eight sub-themes emerged with respect to everyday life challenges and experiences of the rehabilitation programme. The themes were (1) Personal insight and knowledge, (2) Changed daily routines at home and (3) Coping with working life. CONCLUSION: Participants experienced long-term effects of COVID-19 as cognitive challenges, fatigue and headaches, which affected their everyday lives, that is inability to overcome daily tasks at home and at work, maintaining family roles and relations with relatives. The rehabilitation programme contributed to a vocabulary and insights related to the long-term effects of COVID-19 and the experience of being a different person. The programme contributed to changes in daily routines, organising breaks in everyday life and explaining challenges to family/relatives and the way in which they affected daily routines and their role in the family. In addition, the programme supported several of the participants in finding the right workload and working hours. RELEVANCE TO CLINICAL PRACTICE: We recommend multidisciplinary rehabilitation programmes inspired by cognitive remediation of long-term COVID-19 cognitive effects. Municipalities and organisations could collaborate in the development and completion of such programmes, possibly comprising both virtual and physical elements. This could facilitate access and reduce costs. PATIENT OR PUBLIC CONTRIBUTION: Patients contributed to the conduct of the study by participating in the data collection via interviews. CLINICAL TRIAL REGISTRATION NUMBER: Data collection and processing of data are approved by the Region of Southern Denmark (journal number: 20/46585).

Working (and Living) During Corona Times and Implications for Planning and Mobility—The Case of Norway

The COVID-19 pandemic has relatively affected the Norwegian context and other Nordic countries (except for Sweden), considering the prudential authorities and policies adopted during the various waves of the virus. The capacity for remote working and high flexibility of working (already observed before the pandemic) have contributed to adapt to the changes. In this context, the study aims to explore the ways of working and living during the Corona Times and the implications for planning and mobility in Norway, considering the short-medium and long-term effects of the pandemic. First, the study presents an overview of the main impacts of the pandemic in the Nordic countries (such as mortality, labour market and absence from work, including the closure of workplaces), and second, it focuses on Norway, in light of the national measures. Then, the working related trends (for example, growth of demand of new working spaces and the increased number of workers in the public libraries) are discussed, as well as the major implications for our cities, such as new housing demands, commuting habits and transportation modes. Finally, an overview of the current debate within the Norwegian society shows the high interests of planners, other experts, and media in understanding the future of work, such as hybrid forms, new jobs, working remotely (but from where?). © 2023, The Author(s).

Introduction to the Effects of the COVID-19 Pandemic on Coworking

The current chapter introduces in detail the aims and structure of the book ‘European Narratives on Remote Working and Coworking during the COVID-19 Pandemic'. This introductory chapter depicts the importance of studying the phenomenon of coworking spaces (CSs) affected by the COVID-19 pandemic. The literature on new working spaces, particularly CSs, is growing fast in various disciplines. During the past three years of the pandemic, some scholars have attempted to explore the short- and long-term effects on ways and spaces of working. This book is the first attempt to collect country-specific empirical studies from 12 European countries. © 2023, The Author(s).

The Impact and Complex Effects of the COVID-19 Pandemic on the Working Environment and the Use of Coworking Spaces in Malta

Coworking spaces in Malta have grown in their presence and use only within the last decade, yet the COVID-19 pandemic may have altered the cultural working office norms of Maltese society. Indeed, this chapter, using in-depth interviews with different groups of people, that is, co-worker owners, employees, traditional employers and members of an employment association, aims to explore how the pandemic may be impacting the coworking industry in complex ways. From the narratives, it emerged that the soft lockdown measures related to the pandemic had caused immediate negative effects due to the fear of contagion on the use of coworking spaces in Malta and the limitations related to social distances in workspaces. However, the pandemic itself may have created a shift within the Maltese context where the idea of remote working is perceived as beneficial and may become more popular. The pandemic may have contributed to the revision of the Maltese employers' priorities, such as the importance of owning or renting a permanent office space or giving permission to employees to work from home or renting a coworking space for socialisation at work. Therefore, the pandemic may have caused damaging short-term effects to the coworking industry in Malta yet possibly beneficial long-term effects. © 2023, The Author(s).

Impacts of COVID-19 Pandemic on Italian Electricity Demand and Markets

In this paper, the short-, medium-, and long-term effects of the COVID-19 pandemic on the Italian power system, particularly electricity consumption behavior and electricity market prices, are investigated by defining various metrics. The investigation reveals that COVID-19 lockdown caused a drop in load consumption and, consequently, a decrement in day-ahead market prices and an increase in ancillary service prices. © 2015 CSEE.

Long-Term effects of COVID-19: a review of current perspectives and mechanistic insights.

Although SARS-CoV-2, responsible for COVID-19, is primarily a respiratory infection, a broad spectrum of cardiac, pulmonary, neurologic, and metabolic complications can occur. More than 50 long-term symptoms of COVID-19 have been described, and as many as 80% of patients may develop ≥1 long-term symptom. To summarize current perspectives of long-term sequelae of COVID-19, we conducted a PubMed search describing the long-term cardiovascular, pulmonary, gastrointestinal, and neurologic effects post-SARS-CoV-2 infection and mechanistic insights and risk factors for the above-mentioned sequelae. Emerging risk factors of long-term sequelae include older age (≥65 years), female sex, Black or Asian race, Hispanic ethnicity, and presence of comorbidities. There is an urgent need to better understand ongoing effects of COVID-19. Prospective studies evaluating long-term effects of COVID-19 in all body systems and patient groups will facilitate appropriate management and assess burden of care. Clinicians should ensure patients are followed up and managed appropriately, especially those in at-risk groups. Healthcare systems worldwide need to develop approaches to follow-up and support patients recovering from COVID-19. Surveillance programs can enhance prevention and treatment efforts for those most vulnerable.

The long-term effects of Kerala Diabetes Prevention Program on diabetes incidence and cardiometabolic risk: a study protocol.

INTRODUCTION: India currently has more than 74.2 million people with Type 2 Diabetes Mellitus (T2DM). This is predicted to increase to 124.9 million by 2045. In combination with controlling blood glucose levels among those with T2DM, preventing the onset of diabetes among those at high risk of developing it is essential. Although many diabetes prevention interventions have been implemented in resource-limited settings in recent years, there is limited evidence about their long-term effectiveness, cost-effectiveness, and sustainability. Moreover, evidence on the impact of a diabetes prevention program on cardiovascular risk over time is limited. OBJECTIVES: The overall aim of this study is to evaluate the long-term cardiometabolic effects of the Kerala Diabetes Prevention Program (K-DPP). Specific aims are 1) to measure the long-term effectiveness of K-DPP on diabetes incidence and cardiometabolic risk after nine years from participant recruitment; 2) to assess retinal microvasculature, microalbuminuria, and ECG abnormalities and their association with cardiometabolic risk factors over nine years of the intervention; 3) to evaluate the long-term cost-effectiveness and return on investment of the K-DPP; and 4) to assess the sustainability of community engagement, peer-support, and other related community activities after nine years. METHODS: The nine-year follow-up study aims to reach all 1007 study participants (500 intervention and 507 control) from 60 randomized polling areas recruited to the original trial. Data are being collected in two phases. In phase 1 (Survey), we are admintsering a structured questionnaire, undertake physical measurements, and collect blood and urine samples for biochemical analysis. In phase II, we are inviting participants to undergo retinal imaging, body composition measurements, and ECG. All data collection is being conducted by trained Nurses. The primary outcome is the incidence of T2DM. Secondary outcomes include behavioral, psychosocial, clinical, biochemical, and retinal vasculature measures. Data analysis strategies include a comparison of outcome indicators with baseline, and follow-up measurements conducted at 12 and 24 months. Analysis of the long-term cost-effectiveness of the intervention is planned. DISCUSSION: Findings from this follow-up study will contribute to improved policy and practice regarding the long-term effects of lifestyle interventions for diabetes prevention in India and other resource-limited settings. TRIAL REGISTRATION: Australia and New Zealand Clinical Trials Registry-(updated from the original trial)ACTRN12611000262909; India: CTRI/2021/10/037191.

A Survey of the Various Methods and Models Used to Detect Long COVID

Long-COVID or post-COVID is a phenomenon where people who have recovered from the COVID-19, suffer persisting symptoms for more than 4 weeks after the confirmed case of COVID-19 and they can last for months. Approximately 20% of the people affected by this Coronavirus disease (COVID-19) are suffering from mid and long term effects known as the Long COVID and it can affect multiple organs in the body and this can lead to death. To date, different studies and researches have been undertaken to understand about the Long COVID and make robust estimates on the predicting factors, symptoms and also to assess the various long term effects on the patients affected by it. Based on the available research articles and the papers published in mainstream journals on Long COVID, this survey paper aims at analyzing various methods and Machine learning models used to detect and predict Long COVID, to help clinicians and researchers working on early diagnosis of Long COVID. © 2022 IEEE.

Potential impacts of the Covid-19 pandemic on the future of travel demand

The Covid-19 pandemic has dramatically cut the amount people travel, with possible long-term effects on demand. Greg Marsden of the University of Leeds says civil engineers need to reconsider how they plan future transport infrastructure accordingly.

Are mRNA COVID 19 vaccines safe in long COVID patients? A health care workers perspective

Introduction: Long Covid patients may have concerns about the impact of mRNA vaccines on their symptoms. Method: A short questionnaire was sent to users of a long covid service supporting an NHS Trust staff in Wigan 2 weeks following the conclusion of a mRNA vaccine first dose roll out. The questionnaire explored acceptance and compliance with the vaccine and any change in the symptoms at least 2 weeks following the vaccination. Results: 77 HCW were offered the vaccine. 10 respondents declined mainly because of concerns regarding worsening long covid symptoms. 67% of respondents did not experience any change in symptoms whilst 21% experienced improvement of symptoms. 12% experienced worsening of symptoms. Conclusion: mRNA vaccines can influence long covid symptoms. However, patients seemed to be twice more likely to experience improvement than worsening of symptoms.

Estimating post-pandemic effects of working from home and teleconferencing on travel behaviour

Like in many other countries, the Dutch government instructed people to work from home where possible during the COVID-19 pandemic to halt the transmission of the virus. This policy seems to have resulted in a structural increase in working from home and teleconferencing that will outlast the pandemic. However, the longer-term effects on travel behaviour are still unclear. Making use of panel data collected using the Netherlands Mobility Panel, this paper has two main aims. First, it analyses developments in working from home and teleconferencing since COVID-19. Second, it estimates the expected post-pandemic effects on travel behaviour. The results show that compared to before the pandemic, the average number of hours that people work from home has doubled and roughly two-thirds of respondents indicate that they teleconference more often. We estimate that structural, post-pandemic increases in working from home and teleconferencing will result in a negative effect on distances travelled by train (-3% to-9%), by bus, tram, and metro (-1% to-5%) and car (-1 to-5%). The estimated effect on the distance travelled by bicycle (-2% to 0%), and walking (0% to +1%) is smaller or even positive, due to people making more complementary trips for other purposes when working from home. When interpreting these results, we should keep in mind that due to various other factors, such as population growth, total travel demand will still grow in the near future. © 2023, TU Delft. All rights reserved.

Long COVID in the United States

Although yet to be clearly identified as a clinical condition, there is immense concern at the health and wellbeing consequences of long COVID. Using data collected from nearly half a million Americans in the period June 2022-December 2022 in the US Census Bureau's Household Pulse Survey (HPS), we find 14 percent reported suffering long COVID at some point, half of whom reported it at the time of the survey. It peaks in midlife in the same way as negative affect. Ever having had long COVID is strongly associated with negative affect (anxiety, depression, worry and a lack of interest in things). The effect is larger among those who currently report long COVID, especially if they report severe symptoms. In contrast, those who report having had short COVID report higher wellbeing than those who report never having had COVID. Long COVID is also strongly associated with physical mobility problems, and with problems dressing and bathing. It is also associated with mental problems as indicated by recall and understanding difficulties. Again, the associations are strongest among those who currently report long COVID, while those who said they had had short COVID have fewer physical and mental problems than those who report never having had COVID. Vaccination is associated with lower negative affect, including among those who reported having had long COVID.

Long COVID: new treatment perspective using nutraceuticals

Coronavirus disease (COVID-19) is an ongoing worldwide pandemic affecting a large population regardless of gender, age, and ethnicity. The persistence of the COVID-19 symptoms has become a significant health issue and is collectively called "Long COVID". It can be described as the presence of symptoms of COVID even after the recovery from the viral infection. The prolonged symptoms in the patients could be due to various reasons and factors. Prolonged fatigue is a common symptom of Long COVID in patients even after they have recovered from the viral infection. Currently, only rehabilitation has shown promising results in managing the symptoms of Long COVID. Although pharmaceutical drugs have shown potential in treating the symptoms of Long COVID, more clinical evidence is required to confirm its treatment with less to no side effects;since it's a new disease, the in-depth knowledge of the same is still evolving. Another healthier approach to treating the symptoms of Long COVID could be dietary supplements or "Nutraceuticals", identified as an alternative to pharmaceuticals, including nutritional supplements, derived nutrients, and dietary and herbal products that display physiological advantages. Nutritional strategies can also play a role in treating hospitalized patients as maintaining the immune system is critical to combat viral infection. Nutraceuticals may be a practical and healthier approach to managing the symptoms of Long COVID or COVID-19. Although ample clinical evidence is present for the treatment of symptoms of COVID-19, further studies in treating Long COVID or its symptoms are required.

An Evidence Study of Long-term Impacts on Mobility Patterns Brought by COVID-19

The outbreak of COVID-19 at the end of 2019 has posed an enormous threat to people's physical and psychological health, especially those who are infected during the epidemic. Understanding how the infected people behaved during the pandemic and whether long-term effects are exerted even after they were cured is essential for guiding them to conduct a more comprehensive recovery. Large scale crowd-sourced data provides a chance to investigate their behavior patterns. In this paper, we explore the possible differences in mobility patterns between the infected and the uninfected, relying on a large volume of crowd -sourced location data contributed by smartphone users consisting of 11,414 infected cases and 12,793 uninfected people between Jun. 1, 2019 and Dec 31, 2020 in Wuhan, China. We characterize mobility distinctions of the two groups by introducing five mobility indicators that accurately capture spatio-temporal patterns of human mobility. We reveal that the infected kept higher mobility level during the pandemic. Moreover, the COVID-19 caused lower recovery efficiency on mobility of the infected, including later recovery time, lower speed and worse status. © 2022 IEEE.

Potential of Black Seeds (Nigella sativa) in the Management of Long COVID or Post-acute Sequelae of COVID-19 (PASC) and Persistent COVID-19 Symptoms - An Insight.

BACKGROUND: Some individuals may experience symptoms persisting for many months after the recovery from COVID-19 and patients with Long COVID are managed mainly with symptomatic treatment and supportive care. OBJECTIVE: This review article focuses on the beneficial effects of black seeds (Nigella sativa) in the management of long COVID and persistent COVID symptoms. METHODS: The literature was searched in databases such as LitCOVID, Web of Science, Google Scholar, bioRxiv, medRxiv, Science Direct, EBSCO, Scopus, Embase, and reference lists to identify studies, which evaluated various effects of black seeds (N. sativa) related to signs and symptoms of long COVID. RESULTS: Black seeds (N. sativa) have shown potential anti-COVID, antiviral, anti-inflammatory, antioxidant, immunomodulatory, antihypertensive, anti-obesity, antidiabetic, antihyperlipidemic, and antiasthmatic properties in various clinical, animal, in vitro, in vivo, and in silico studies, which would help the patients recovered from COVID to mitigate Long COVID complications. CONCLUSION: Patients experiencing Long COVID may use black seeds (N. sativa) as adjunctive therapy in combination with symptomatic treatment and supportive care to prevent further deterioration and hospitalization. The safety and efficacy of N. sativa in patients with Long-COVID would further be established by future randomized controlled clinical trials.

Life and Stress of Japanese Children and Adolescents During the Prolonged Coronavirus Disease 2019 (COVID-19) Pandemic

This study surveyed adult web monitor enrollees about the lives of and stress experienced by Japanese children and adolescents during the prolonged coronavirus disease 2019 (COVID-19) pandemic. The survey was conducted on February 10, 2022 (after the sixth wave) and August 19, 2022 (during the seventh wave of the COVID-19 pandemic in Japan), with 231 and 217 survey participants, respectively. The questionnaire was designed so that adults could assess the frequency of exercise, and difficulties experienced by children and adolescents around them. Regarding exercise opportunities, 22% of parents of middle and high school children reported that children's exercise opportunities "stayed the same” or "increased considerably” in the first survey. Whereas, in the second survey, all parents of middle and high school children reported that children's exercise opportunities "decreased.” Regarding stress, 17% of parents of adolescents 18 years and older responded that the stress experienced was the "same as before” or "a little less than before” in the first survey, but all of these parents responded "quite a bit” to the same question in the second survey. The findings suggest that the life changes caused by the COVID-19 pandemic may have a significant impact on children and adolescents and may increase stress. The long-term effects of the COVID-19 pandemic on children and adolescents should be further investigated. © Fuji Technology Press Ltd.

Long-term cardiovascular health status and physical functioning of non-hospitalized COVID-19 patients compared to non-COVID-19 controls.

Coronavirus disease 2019 (COVID-19) is reported to have long-term effects on cardiovascular health and physical functioning, even in the non-hospitalized population. The physiological mechanisms underlying these long-term consequences are however less well-described. We compared cardiovascular risk factors, arterial stiffness and physical functioning in non-hospitalized COVID-19 patients, at a median of six months post-infection, versus age- and sex-matched controls. Cardiovascular risk was assessed using blood pressure and biomarker concentrations (amino-terminal pro-B-type-natriuretic-peptide, high-sensitive cardiac troponin I, C-reactive protein) and arterial stiffness was assessed using carotid-femoral pulse wave velocity. Physical functioning was evaluated using accelerometry, handgrip strength, gait speed and questionnaires on fatigue, perceived general health status and health-related quality of life (hrQoL). We included 101 former COVID-19 patients (age 59 (interquartile range: [55-65]) years, 58% male) and 101 controls. At 175 [126-235] days post-infection, 32% of the COVID-19 group reported residual symptoms, notably fatigue, and 7% required post-COVID-19 care. We found no differences in blood pressure, biomarker concentrations or arterial stiffness between both groups. Former COVID-19 patients showed a higher handgrip strength (43 [33-52] versus 38 [30-48] kg, p=0.004), less sleeping time (8.8 [7.7-9.4] versus 9.8 [8.9-10.3] hours/day, p<0.001) and reported fatigue more often than controls. Accelerometry-based habitual physical activity levels, gait speed, perception of general health status and hrQoL were not different between groups. In conclusion, one in three non-hospitalized COVID-19 patients reports residual symptoms at a median of six months post-infection, but we were unable to relate these symptoms to increases in cardiovascular risk factors, arterial stiffness or physical dysfunction.

Post-COVID-19 prolonged neurological symptoms and characteristics: A face-to-face survey study

Background: COVID-19 was declared as a pandemic by World Health Organization on March 11, 2020, and still constitutes a serious health problem affecting millions of people across the world. The evaluation and follow-up of ongoing and/or newly developing neurological involvement after recovery from COVID-19 are important. This study aims to reveal post-COVID-19 neurological symptoms and risk factors for their development. Method(s): Patients over the age of 18 years who applied to centers, at least 4 weeks after COVID-19 infection and agreed to participate in the study were included in this cross-sectional study between January 20 and March 15, 2021. The patients were evaluated face to face, and their sociodemographic data, medical history, post-COVID-19 neurological symptoms, treatments, and Beck Depression Inventory scores were recorded. All statistical analyses were performed using SPSS 23 for Windows software package (SPSS Inc., Chicago, IL). Result(s): Four hundred patients were included in this study, an average of 108+5.12 days had passed after the onset of COVID-19. The rate of post-COVID-19 neurological involvement was 73.3%, and the top 3 most common symptoms were headache (47%), myalgia (43%), and sleep disturbance (39%). Having depression (OR: 4.54, 95% Cl:1.88-10.96), female gender (OR:2.18, 95% Cl:1.36-3.49), hospitalization (OR: 2.01, 95% Cl:103-3.64), and usage of favipiravir (OR:2.07 95 Cl:1.15-3.72) were determined as independent predictors of developing prolonged neurological symptoms. Conclusion(s): The long-term consequences of COVID-19 remain uncertain. It should be remembered that neurological symptoms are very common in post-infectious patients and long-term follow-up may be required in the management of this condition. Copyright © 2022, ASEAN Neurological Association. All rights reserved.

Identifying long-term effects of SARS-CoV-2 and their association with social determinants of health in a cohort of over one million COVID-19 survivors.

BACKGROUND: Despite an abundance of information on the risk factors of SARS-CoV-2, there have been few US-wide studies of long-term effects. In this paper we analyzed a large medical claims database of US based individuals to identify common long-term effects as well as their associations with various social and medical risk factors. METHODS: The medical claims database was obtained from a prominent US based claims data processing company, namely Change Healthcare. In addition to the claims data, the dataset also consisted of various social determinants of health such as race, income, education level and veteran status of the individuals. A self-controlled cohort design (SCCD) observational study was performed to identify ICD-10 codes whose proportion was significantly increased in the outcome period compared to the control period to identify significant long-term effects. A logistic regression-based association analysis was then performed between identified long-term effects and social determinants of health. RESULTS: Among the over 1.37 million COVID patients in our datasets we found 36 out of 1724 3-digit ICD-10 codes to be statistically significantly increased in the post-COVID period (p-value < 0.05). We also found one combination of ICD-10 codes, corresponding to 'other anemias' and 'hypertension', that was statistically significantly increased in the post-COVID period (p-value < 0.05). Our logistic regression-based association analysis with social determinants of health variables, after adjusting for comorbidities and prior conditions, showed that age and gender were significantly associated with the multiple long-term effects. Race was only associated with 'other sepsis', income was only associated with 'Alopecia areata' (autoimmune disease causing hair loss), while education level was only associated with 'Maternal infectious and parasitic diseases' (p-value < 0.05). CONCLUSION: We identified several long-term effects of SARS-CoV-2 through a self-controlled study on a cohort of over one million patients. Furthermore, we found that while age and gender are commonly associated with the long-term effects, other social determinants of health such as race, income and education levels have rare or no significant associations.